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Furthermore, gut dysbiosis reduces the activity of bile salt hydrolase and 7-dehydrogenase, leading to decreased levels of secondary bile acids (e.g., lithocholic acid) and insufficient activation of TGR5

10.1111/jnc.14604 J

2012;5:ra77

doi: 10.1007/s00394-018-1790-2 37 ZhangCYLiuTHWangW
