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DPOAE detected ototoxicity in 48% on day 7, 66% on day 14, 70% on day 28, and 77% at day 56 of streptomycin treatment, whereas hearing loss was detected by pure tone audiometry in only 2% on day 7, 11% on day 14, 22% on day 48, and 29% on day 56

and the SIRIC Cancer Research and Personalized Medicine (CARPEM)

Researchers call this sickness behavior. It is the same combination of fatigue, body aches, mental slowness, and appetite loss your body produces when fighting a mild illness which is exactly why a bad hangover can feel indistinguishable from the early stages of the flu

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Cystine forms a complex with cystathionine -lyase (most often designated CSE) and the a-subunit of the E1 portion of the PDH complex (PDHc) which is encoded by the PDHA1 gene