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10.1152/ajpheart.00372.2017 62

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They have been shown to be superior to clinical judgment alone, and should be used in conjunction with typical clinical criteria, such as presence of comorbid conditions, age, and first episode of pancreatitis

An increased number of receptors (up-regulation of receptor synthesis) results in an increased uptake of LDL cholesterol from the blood, with a subsequent reduction of LDL cholesterol levels