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However, studies show that the consumption of herbal supplements rich in thiaminase during pregnancy ( in utero ( A number of hypotheses have been put forward on the pathophysiological mechanisms linking thiamine deficiency and ASD ( More interestingly, a subset of children with ASD has been characterized by PDH deficiency and mitochondrial dysfunction ( Based on the finding that children with ASD seem to have an impairment in the catabolism and excretion of thiol-containing heavy metals, Lonsdale et al

Each time the blood lead level was diminished, additional lead was mobilized from the tissues and bones