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In rare cases, a severe vitamin C deficiency can cause you to develop scurvy, marked by: Fatigue Joint and muscle pain Swollen and spongy gums Red spots on the skin Children with a vitamin D deficiency can develop rickets, which manifests as poor growth, deformities, and bone pain

Notably, a polymorphism in the ABCC2 gene has also been suggested to lead to higher oxaliplatin concentration in neurons, and was associated with oxaliplatin induced neuropathy (Mori et al., 2008)

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Thiamine also appears to have direct anti-inflammatory effects in the gut of ruminant animals, showing a reduction in intestinal permeability through enhanced production of barrier proteins, protection against bacterial lipopolysaccharide-induced inflammation, and improved barrier function

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