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In this context, it could be shown in vivo that DUX4 -induces binding of specificity protein 1 ( sp1 ) to p21 promoter [129]

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Beside the presence of neurofibromas, benign tumors that hallmark this disorder, gliomas, hematological neoplasms, breast cancer, pheochromocytomas, gastrointestinal tumors (GISTs) and MPNSTs may develop throughout lifetime