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Workflow of GRX reduction of glutathionylated proteins Each method offers distinct strengthswhether for targeted validation or comprehensive redox proteome mappingand can be selected based on the study's scale, sensitivity needs, and sample type

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J Pharmacol Exp Ther 2010;33:161-73

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3eg), low glucose, known to open calcium channel and lead to extracellular calcium influx, significantly enhanced the calcium response in GCGR-KO cells, suggesting increased extracellular calcium influx