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It can also intravenously be used when a rapid onset of diuresis is desired as in acute pulmonary edema, or when gastrointestinal absorption is impaired or oral medication is not possible [1, 2]

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However, the safety and feasibility of this approach has not been fully validated in humans, and a number of potential issues need to be addressed, such as the precision of gene editing, nonspecific side effects, effective vectors and delivery systems, and ethical and legal regulations