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This phase 3 trial directly compares CagriSema 2.4 mg/2.4 mg against tirzepatide 15 mg in approximately 800 adults with obesity

However, its C-terminal end can be cleaved by carboxypeptidase A, and removal of the last leucine residue (L585) weakens receptor binding, reducing its half-life from 20 days to 3.5 days in humans

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Overall, the two main goals of treatment are reducing recovery time and preventing ocular complications
