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Description
This mitochondrial gridlock is the biochemical basis for post-exertional malaise (PEM), the hallmark symptom of ME/CFS where patients experience a devastating crash in physical and cognitive function after minor exertion
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Knowing your status can inform how aggressively you pursue BDNF-boosting strategies, though exercise, peptides, and lifestyle interventions benefit all genotypes
Neuron 53: 249260 [DOI] [PubMed] [Google Scholar] Bloodgood BL, Giessel AJ, Sabatini BL 2009
Still unsure whether to go oral or injectable
