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Our data suggest that the LCS encapsulation platform could be utilized as a robust vehicle for sensitive phytocompounds where its systemic protective profile may contribute to its preclinical benefit

Hydrogenolysis allowed to remove the N- and O-protecting groups and was followed by the spontaneous cyclization to a pyrrolidine-2-one (3 S ,4 S ,5 R )- 123 [111]

Funding This work was supported by the: Parkinson Research Consortium of Ottawa (J.M.T., D.N.E.K., T.K.F., J.J.T., A.C.)

Potential Therapeutic Applications of MnSODs and SOD-Mimetics

Amyloid protein, on the other hand, is implicated in regulation of synaptic function, improving memory and protection of neurons from oxidative stress ( Probably the most significant form of amyloid related neuropathy is associated with -synuclein, a major neurosynaptic chaperone which mediates release of neurotransmitters (Sulzer and Edwards, 2019)