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Metformin decreases hepatocellular carcinoma risk in a dose-dependent manner: population-based and in vitro studies

El riesgo de experimentar efectos secundarios es mayor si se excede la dosis recomendada

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Materials and methods An extensive literature search was carried out independently on online databases (MEDLINE via PubMed, ISI Web of Science, and Scopus), by four reviewers (RMR, EM, LC, and CV) independently of each other, to identify relevant studies published between January 2005 and June 2025