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Strategic combination often produces better outcomes than any single approach alone

doi: 10.1016/S0026-0495(98)90074-9 52 AceriniCLPattonCMSavageMOKernellAWestphalODungerDB

As a state, a depressive mood may be an adaptive stress response ( Clinical response is usually noticeable after 25 weeks ( The difficulties in modeling depression and neuropsychiatric disorders in experimental non-human species may, in part, be attributed to the variability of depressive symptoms (across and within individuals), and the sheer impossibility to reproduce in non-human animals some important features, such as guilt and suicidality

Its observed effects on neuronal protection and signaling balance suggest potential relevance to cognitive processes such as memory retention and mental clarity

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