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After the initiation of a low-caloric diet in studies with mice, a reduction of leptin levels and an elevation of corticosterone (due to the anxiety responses following the withdrawal or reduction of food) were observed

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10.1111/j.1365-2982.2010.01620.x 342 NiccolaiE.MartinelliI.QuarantaG.NanniniG.ZucchiE.De MaioF.et al

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Mainstream clinical practice faces major barriers with respect to the high expenses needed for developing and optimizing nanoparticle-based treatments