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This fact is related to the lack of randomized study fulfilled the criteria of evidence based-medicine in this field of medicine

Medicine 98:e18453

The role of zonulin in T1D was further reinforced by Watts and colleagues who demonstrated that T1D-associated symptoms could be alleviated in disease-prone rodent models following administration of a zonulin inhibitor (Watts et al

Within this framework, simple ratios such as the neutrophil-to-lymphocyte ratio have become well-established, practical, and readily accessible biomarkers across diverse disease settings (92)

Co-culture systems involving neurons, microglia, and astrocytes could elucidate the complex interactions within the neuroimmune network and provide deeper insights into the multifaceted roles of Irisin