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found that irisin-mediated p53 reduction decreases ferroptosis and protects cardiomyocytes against high-glucose injury by increasing SIRT1, decreasing p53 K382 acetylation to promote p53 degradation, and consequently upregulating SLC7A11 and GPX4 [108]

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The underlying mechanisms include, IGF-1-induced up-regulation of the Na-Pi 2a cotransporter in the renal proximal tubules, as well as enhanced intestinal phosphate absorption, due to GH-induced increased calcitriol synthesis ( vide supra )

Conclusions l-Carnitine administration may have potential for the prevention of POAF in aortic valve surgery

doi: 10.1093/jxb/erw238