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Several conditions produced labile crystal plates

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Although growing evidence suggests a role for endosomal PI(4,5)P 2 in cell physiology 4 , our results demonstrate that highly redundant functions of PI(4,5)P 2 phosphatases and SMP proteins keep levels of endosomal PI(4,5)P 2 below a certain threshold to prevent failure of cytokinesis and animal development in vivo

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