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An animal study showed that copper supplementation in the drinking water of mice with quinolinic acid (QUIN)-induced HD had a neuroprotective effect (139)

The trial lasted 48 weeks with a standardized lifestyle intervention including diet counseling and physical activity recommendations

Ann Surg Oncol 29(2):1172-1179, 2022

10.2165/00003088-199700321-00003 105 PrincipiN.PetropulacosK.EspositoS

Cosubstrate depletion has been observed in animals with very large doses of drugs (e.g
