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Intranasal administration, though less studied with Dihexa specifically, would theoretically provide the most direct CNS delivery with minimal systemic exposurepotentially requiring even less frequent dosing to maintain effective brain tissue concentrations

Washington, DC, American Chemical Society, 1983, pp 175196 Sikiric P, Rotkvic I, Mise S, Kriznac S, Suchanek E, Petek M, Gjuris V, Tucan-Foretic M, Udovicic I, Anic T, Balen I: The influence of dopamine agonists and antagonists on gastric lesions in mice

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