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Description
TFAM binds to mitochondrial DNA between 1435 bp upstream of the LSP transcription start site

When its depleted, everything from immune function to cognitive performance suffers

The consistent clinical failure of agents targeting a single mode of cell death provides compelling clinical validation for the mechanistic principle outlined in Section 2.4.2: MIRI triggers an interconnected web of cell death programs, suggesting future strategies may need to be multi-modal or target more upstream events

Barbato G, Cicero DO, Nardi MC et al (1999) The solution structure of the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanism
However, these intervals often lack broad applicability due to small sample sizes and insufficient stratification by gender and/or age
