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however, none has been further evaluated in animal models, and thus, it remains unclear whether they will be effective in vivo

Canas PM, Duarte JM, Rodrigues RJ, Kfalvi A, Cunha RA (2009) Modification upon aging of the density of presynaptic modulation systems in the hippocampus

J Pelv Med Surg

The recommended initial dose is 15 mg/kg/day, increasing at one week intervals by 5 to 10 mg/kg/day until seizures are controlled or side effects preclude further increases