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EB, a DNA-alkylating agent, kills astrocytes and oligodendrocytes while sparing axons 139,140 , whereas LPC disrupts oligodendrocyte membranes via detergent-like effects 141,142

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Senescent cells deactivate these pathways, which include various molecules such as ephrins, PI3K isoforms, p53/p21CIP1, HIF-1, plasminogen-activated inhibitors 1 and 2, and Bcl-2 family members
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