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Furthermore, geographic location, baseline selenium levels, habitual iodine intake, and disease stage may all affect an individuals reaction to supplementation [2,29,33,35,39]
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Ggotek A, et al

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Decoupling the assay by first starting the transaminase reaction followed by addition of the dehydrogenase did not alter overall velocities concluding that the dehydrogenase reaction must be the rate limiting step in the reaction