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Pharmacokinetics, safety, and tolerability of oral semaglutide in subjects with hepatic impairment

Critically, AOD-9604 did not produce the metabolic side effects associated with full-length growth hormone, including no insulin resistance or glucose intolerance, no elevation of IGF-1 levels, no fluid retention or joint pain, and no cardiovascular parameter changes

Special Considerations: Do not use in patients with G6PD deficiency or severe kidney disease Use caution in those with a history of nephrolithiasis or oxalate metabolism disorder

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