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(3) Directly validated to participate in physiological thermoregulation (warm sensing or heat-defense effector regulation) via in vivo / in vitro functional studies (electrophysiology/optogenetics/chemogenetics)

While in vitro and animal studies exist, robust human clinical trials on many herb-drug interactions are often limited, making it difficult to predict precise effects in patients (245247)

Autophagy promotes metastasis and glycolysis by upregulating mct1 expression and wnt/-catenin signaling pathway activation in hepatocellular carcinoma cells

Sun Z, SU J, Zhai X, Tang W

Food and Drug Administration (FDA) announced a recall of the LivaNova VNS Therapy SenTiva Generator due to an unintended reset error that causes the system to stop delivering VNS therapy