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This linker typology is the result of the binding of TLM to ELM through click-chemistry reactions, i.e., a copper-catalyzed huisgen 1,3-dipolar cycloaddition reaction between azides and alkyne groups, under mild chemical conditions 167

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Compared to other derivatives, artemisinin ether derivatives are more fat-soluble but less water-soluble, with low bioavailability ( Artemisinin and their derivatives have a wide range of pharmacologic effects, including anti-inflammatory, antioxidant, antifibrotic, and antitumor effects, in addition to their broad-spectrum antimalarial activity

The most extensively studied IGF-1R TKI is the ATP-competitive Linsitinib, but disappointing results were reported in numerous trials