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ROS are closely associated with hypertensions major pathogenic features, including endothelial dysfunction, vascular hyperreactivity, vascular injury, arterial remodeling, renal impairment, sympathetic nervous system activation, inflammation, and immune cell activation [244, 246]

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doi: 10.1128/AEM.02299-19 198 WangY.LiuF.LiuH.ZhangY.JiaoX.YeM.et al

More recently, a breakthrough 2026 study utilizing both in-vitro cellular models and an in-vivo human pharmacokinetic trial further solidified these findings