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This kind of anti-osteoporotic effects were mediated by the downregulation of JNK/p38 MAPK, NF-B and PI3K-AKT signaling pathways that can be stimulated by RANKL

Lan M, Zhao S, Liu W, Lee CS, Zhang W, Wang P

10.1002/ana.410320612 [DOI] [PubMed] [Google Scholar] Kuhn D

G protein-coupled receptor (GPCR) is a 7-transmembrane protein receptor containing a G protein-binding region in the cytoplasm and a ligand-binding region outside the cell

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