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The peptide has also been successfully tested for vascular injury and blood flow disturbances in rats, particularly in cases of lab-induced vessel occlusion of the mesenteric vein and pancreaticoduodenal vein

This cell increase was further corroborated by immunohistochemistry visuals

Similarly, NO that has been reported to be stimulated by the peptide [ 115 ] through the impact on endothelial NO synthase (eNOS) has also been known for its stimulatory role in angiogenesis and mediating activity of various angiogenic molecules [ 116 118 ]

Sayers made use of direct injection air embolism as a murder method in her 1927 Lord Peter Wimsey mystery novel Unnatural Death (published in the US in 1928 as The Dawson Pedigree ), although her description was subsequently criticised as implausible on account of the injection site and volume