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What the Animal Studies Show The overwhelming majority of BPC-157 research 35 of 36 studies in a 2025 systematic review published in Orthopaedic Journal of Sports Medicine has been conducted in animal models, primarily rats
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PMID: 18612058 View source Pickart L, et al
The peptide reduces production of pro-inflammatory cytokines including IL-1, TNF-, and IL-6 while enhancing expression of anti-inflammatory mediators such as IL-10 and TGF-, creating a cytokine milieu that supports tissue repair rather than ongoing damage
