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In addition, the increase in hydrogen peroxide production due to the suppression of GPx1 resulted in a proinflammatory activation of human endothelial cells, as characterized by the upregulation of the adhesion molecules ICAM1 and VCAM1

Furthermore, p62, also known as sequestosome-1 (SQSTM1), is a multifunctional adaptor protein essential for autophagy, cellular signaling, and protein degradation