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To preserve and stabilize enzymes in formulation, technologies have been developed, among them encapsulation using liposome or nanoemulsion, addition of sugar or polyol as cosolute strengthening the hydration shell around the enzyme, or precise pH control matching the isoelectric point ensuring structural stability [193, 194]

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Tophi : a later stage of gout in which crystals build up in your joints or skin

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However, in contrast to T cells that exist in almost all ducts of SG in both pSS and non-SS patients, the B cells that infiltrate the ducts with LELs are more specific to this particular type of lesion (105)

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These multi-purpose biodegradable nanosystems are ultimately used for cancer chemotherapy and gene therapy [67]

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10.1136/openhrt-2015-000300 182

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