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Owing to its location adjacent to the glomeruli and the presence of specific organic acid-base secretion systems, the proximal tubule is often exposed to higher concentrations of toxins compared to other nephron segments, making it the primary site of nephrotoxic damage [ 43 ]

It is of interest that for those with sensation, DGNS may provide a way of decreasing peak pressures during initial detrusor contractions whilst appropriate toileting arrangements are made, thus preserving continence and low pressure storage without MDP ever being reached