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(2020c)

A dose of 250 mg/kg significantly reduces oxidative stress in the myocardium of mice with isoproterenol-induced myocardial infarction, whereas a dose of 10 mg/kg is used to modulate the circadian resetting of clock genes in the rat heart (157,160)

CIH-activated TGF- signaling accelerates lung cancer development through multi-faceted regulation of the TME and tumor cell phenotype: it boosts the migratory capacity of lung cancer cells, activates CAFs, and increases their numbersCAF-ECM crosstalk is pivotal for tumor invasion (Sapudom et al., 2020)

doi:10.1073/pnas.1801609115 7

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