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U.SchulteH

Combination with Inhibitors of Other RTKs and Downstream Effectors RTK Inhibitors Crosstalk between the IGF axis and other RTK signaling pathways (including EGFR, HER2, VEGFR, PGDFR, cMET, and ALK) results in reciprocal compensatory mechanisms that limit response and/or mediate acquired resistance to treatments that target an individual pathway (Fig

Since the treatments mainly consist of vitamins and amino acids, side effects from the substances themselves are rare
Quercetin, a chemo-liable and thermo-liable compound can lower bioavailability at the target site (Cai, Fang, Dou, Yu, & Zhai, 2013)

doi: 10.1159/000363162
