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M., Arciero, P
161 Additionally, a Clostridium -derived metabolite, trimethylamine N-oxide, can activate the endoplasmic reticulum stress kinase protein kinase RNA-like endoplasmic reticulum kinase, leading to gasdermin E-mediated pyroptosis in tumor cells and promoting CD8 + T-cell-driven antitumor responses
However, recent advancements in oral formulations have narrowed this efficacy gap
CB-839 has varied effects on the function of different types of T cells, thereby affecting the immune response
Almourani R, Chinnakotla B, Patel R, Kurukulasuriya LR, Sowers J
