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The physiological role of copper: Dietary sources, metabolic regulation, and safety concerns

Parkinsons disease (PD), Alzheimers disease (AD), and amyotrophic lateral sclerosis (ALS) are the most common neurodegenerative diseases

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In response to the dopaminergic neural activation induced by substances of abuse, such as heroin (119, 120), methamphetamine (121, 122), and cocaine (123), the mitochondrial respiratory chain is rapidly activated, leading to mitochondrial dysfunction, such as decreased mitochondrial membrane potential, mitochondrial DNA, and mitochondrial proteins, and increased cytochrome c release, resulting in increased ROS and oxidative stress (124)

The polyphenol has also been found to modulate mitochondrial dynamics through regulation of fusion and fission proteins, contributing to improved mitochondrial network stability