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We studied VPA toxicokinetics using a nonlinear mixed-effects model-based population approach and modeled individual plasma VPA/blood lactate concentration relationships

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Dysbiosis in CKD has been touted to be due to slow intestinal transit time, delivery of undigested protein to the colon, decreased dietary fiber intake, iron therapy, frequent use of proton pump inhibitors and antibiotics [43]

Finally, it should be mentioned that, in terms of conversion, the best results so far obtained are those reported using the Rhizobium -like, HK1349 strain and -butyrobetaine as substrate