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For instance, in 2023 Zou et al
The roles of DA receptors in the effects of stimulant drugs have been examined in electrophysiological experiments
However, due to the instability of oligonucleotides (half-life less than 1 min), chemical modifications are mandatory, such as the substitution of 2-hydroxyl of the ribose moiety in pyrimidiones by an amino group or fluorine to ameliorate the nuclease resistance to hydrolysis and the replacement of 2-hydroxyl position of purines by 2- O -methyl [19]
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