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O., Larusso N
21 Within the mitochondrial respiratory chain, complexes I and III are the main sites for superoxide radical productionmitochondrial DNA is especially vulnerable to oxidative damage due to its close location to ROS production and limited repair mechanisms

However, NAC is a very acidic compound (pH 2.2), and when inhaled it causes cough and bronchospasm

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GCarusoC.ZellaD.FabioG.et al (2011)
