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Since it is made by the cell, it would make sense to believe that rate of synthesis is regulated by cells

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In addition, it fights against apoptosis and brings beneficial effects to signaling pathways

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Final Considerations Considering the usefulness of contrast agents, the lack of safer alternatives to GBCAs and the higher prevalence of renal complication in GBCA-exposed patients, especially in patients with renal insufficiency when the incidence of chronic kidney disease is increasing worldwide, the studies on the molecular and cellular mechanisms underlying Gd (III) cytotoxicity for each GBCA, as well as their pharmacological effects, are warranted