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The therapeutic effects of MSCs can be mediated through the release of bioactive molecules, including growth factors, cytokines, and extracellular vesicles, which play crucial roles in modulating the local cellular environment, promoting tissue repair, angiogenesis, and cell survival, and exerting anti-inflammatory effects
The hemoglobinemia and hemoglobinuria are present
The peptides increased skin transparency, hyaluronic acid levels, and types I and III collagen, while decreasing MMP-1/3/9, IL-1/6, and TNF-, and increasing TIMPs [35]
doi: 10.1073/pnas.2008373117 99 MuzioL.ViottiA.MartinoG
Conversely, an opposing subset of literature reports elevated BL levels in specific PD subpopulations, likely representing a compensatory physiological response
