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FOXO4-DRI interrupts the interaction between FOXO4 and p53, destabilizing the survival mechanisms of senescent cells

Comprehensive Medicinal Chemistry II

[DOI] [PubMed] [Google Scholar] 196.Kopp F, Hendil KB, Dahlmann B, Kristensen P, Sobek A, Uerkvitz W

This triple-receptor approach positions Retatrutide as the most mechanistically complex metabolic peptide currently in active research , building on the dual-receptor framework of Tirzepatide by adding glucagon receptor co-activation as a third pathway
