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An excessive production of caffeine-dependent gastric hydrochloric acid can affect the degree of absorption of concomitantly used drugs by degrading the drug, converting the drug substance into an insoluble form, and altering its dissolution rate

Wan MJ, Su XY, Zheng Y, et al

Nat Commun

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A single or short-term dose of approximately 50,000 IU can provoke toxic conditions such as vomiting, increased cerebrospinal fluid pressure, blurred vision, and impaired muscle coordination (Eldredge et al., 2022)
