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Full growth hormone administration can stimulate cortisol production through various mechanisms, and elevated cortisol is well-documented to increase appetite, particularly for high-calorie comfort foods, and promote abdominal fat accumulation

The authors thank the members of the Data Safety and Monitoring Board, Boston, MA, and Bangalore, India (Ellis Neufeld, Chair, Leslie Kalish, Arun Mhaskar, and Kishore Phadke)