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The study is well-rounded, with robust in vitro demonstrations in E9 endothelial cells and in vivo studies in Zebrafish larvae and chick embryo models

Another possible factor causing the metabolic transformation of cells into tumor cells is related to the presence of mutations in mitochondria caused by modern life. Enzymes produced by mutated mtDNA are related to cancer development and the use and production of several oncometabolites (Kes et al., 2020)

Statistical analysis Demographical data Normality of the data was assessed, and non-parametric tests were applied for non-normally distributed data

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Ferroptosis Ferroptosis an iron-dependent cell death, different from apoptosis and necrosis, involving three kinds of metabolic pathways: thiol, lipid, and iron, along with lipid iron-dependent peroxidation until cell death