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Another IRE1 activating compound, CXC195, interacts with cysteine 645 in the kinase domain and leads to increased IRE1 scaffolding activity (Rosen et al

Unlike an overdose in humans, it is rarely liver damage that is the cause of death, instead methaemoglobin formation and the production of Heinz bodies in red blood cells inhibit oxygen transport by the blood, causing asphyxiation

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In the context of transcriptomic analyses, it is generally observed that GST expression is downregulated in susceptible interactions (Sun et al., 2016