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Folate and other B vitamins (B2, B12) that provide methyl groups for DNA or histone methylation are produced by the gut microbiota

doi:10.1016/j.clinsp.2025.100654 Liu P, Maharjan R, Wang Y, et al

SAMe (S-adenosyl-methionine) is used to treat depression and joint pain

Studies have shown that carnitine deficiency is associated with a variety of metabolic diseases, including diabetes, obesity, cardiovascular disease, and chronic kidney disease

L-carnitine is considered a conditionally essential nutrient
