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Description
Chronic intermittent hypoxia exerts CNS region-specific effects on rat microglial inflammatory and TLR4 gene expression

The disruption of mechanisms such as oligodendrocyte maturation and migration, myelin phagocytosis, myelin sheath renewal and the inflammation itself are consonant with the full pathological progression of demyelination

p-mTOR: phosphorylated mammalian target of rapamycin
37 , 38 , 39 At the cellular level, insulin resistance affects diabetic neuropathy by damaging insulin signaling in postganglionic neurons and disrupting lipid metabolism in Schwann cells through the PI3K / AKT / mTOR pathway

This suggests the potential therapeutic value of targeting GABAergic systems for improving symptoms in FXS