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The soft tissue injury model was established by mechanical stress

Gastrointestinal issues are frequently the adverse effect of metformin medication that is most commonly observed, affecting 2-63% of T2DM patients, including diarrhea, nausea, vomiting, pain in the abdomen, and flatulence [47]

Role of endothelial NAD+ deficiency in age-related vascular dysfunction

However, the authors of the latter study emphasized the need for further studies to draw more definitive conclusions

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